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Related Concept Videos

Transient Ischemic Attack l: Introduction01:26

Transient Ischemic Attack l: Introduction

A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...
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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...

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Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats
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Recipient twin limb ischemia with postnatal onset.

Roland Spencer Broadbent1

  • 1Department of Women's and Children's Health, Faculty of Medicine, University of Otago, Dunedin, New Zealand. roland.broadbent@stonebow.otago.ac.nz

The Journal of Pediatrics
|January 24, 2007
PubMed
Summary

Limb ischemia in newborns can occur in twins due to twin-twin transfusion syndrome. This condition specifically affects recipient twins after birth, requiring further investigation.

Area of Science:

  • Neonatal care
  • Vascular biology
  • Perinatal medicine

Background:

  • Twin-twin transfusion syndrome (TTTS) is a serious complication of monochorionic pregnancies.
  • It involves unequal placental sharing, leading to significant blood flow disparities between twins.
  • Potential complications include hydrops fetalis, intrauterine growth restriction, and fetal demise.

Observation:

  • Three local cases of neonatal limb ischemia were identified in newborn twins.
  • These cases prompted a systematic literature review to understand the underlying cause.
  • Limb ischemia presented as a postnatal complication in affected infants.

Findings:

  • The review identified a distinct condition: postnatal onset limb ischemia.
  • This condition specifically affects recipient twins within a twin-twin transfusion syndrome pregnancy.

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  • The pathophysiology likely involves vascular compromise secondary to TTTS-related hemodynamic changes.

    • Implications:

    • Early recognition and diagnosis of limb ischemia in TTTS neonates are crucial.
    • Understanding this specific complication can guide clinical management and therapeutic strategies.
    • Further research is warranted to elucidate the precise mechanisms and optimize treatment outcomes.