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Proofreading

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Synthesis of new DNA molecules is carried out by the enzyme DNA polymerase, which adds nucleotides on the daughter strand complementary to the template DNA strand. DNA polymerase has a higher affinity to add the correct base and ensures fidelity during DNA replication. Furthermore, it exhibits proofreading activity during replication, using an exonuclease domain that cuts off incorrect nucleotides from the nascent DNA strand.
Errors During Replication are Corrected by the DNA Polymerase Enzyme

Proofreading

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Synthesis of new DNA molecules starts when DNA polymerase links nucleotides together in a sequence that is complementary to the template DNA strand. DNA polymerase has a higher affinity for the correct base to ensure fidelity in DNA replication. The DNA polymerase furthermore proofreads during replication, using an exonuclease domain that cuts off incorrect nucleotides from the nascent DNA strand.Errors during Replication Are Corrected by the DNA Polymerase EnzymeGenomic DNA is synthesized in...

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Related Experiment Video

Updated: Jul 17, 2026

A Nonsequencing Approach for the Rapid Detection of RNA Editing

A Nonsequencing Approach for the Rapid Detection of RNA Editing

Published on: April 21, 2022

Tandem repeats over the edit distance.

Dina Sokol¹, Gary Benson, Justin Tojeira

¹Department of Computer and Information Science, Brooklyn College of the City University of New York, Brooklyn, NY, USA. sokol@sci.brooklyn.cuny.edu

Bioinformatics (Oxford, England)

|January 24, 2007

Summary

This study introduces an efficient algorithm for identifying all tandem repeats in DNA sequences using edit distance. The new tool aids biologists in exploring DNA structure and function, advancing genetic research.

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Published on: January 20, 2023

Area of Science:

Genomics
Bioinformatics

Background:

Tandem repeats are DNA sequences with multiple contiguous copies of a pattern.
These repeats are crucial in various biological applications, including disease diagnosis and DNA fingerprinting.
Existing tools for exhaustive tandem repeat searching are limited.

Purpose of the Study:

To present a precise definition of tandem repeats based on edit distance.
To develop an efficient and deterministic algorithm for finding all tandem repeats within a sequence.

Main Methods:

Developed an efficient, deterministic algorithm for tandem repeat identification.
Defined tandem repeats precisely using the edit distance measure.

Main Results:

An efficient algorithm for finding all tandem repeats under edit distance was developed.
The algorithm is deterministic and theoretically sound.

Conclusions:

The developed algorithm provides a significant advancement for tandem repeat analysis.
This tool can help uncover novel roles of tandem repeats in DNA and protein structure/function.