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Published on: December 19, 2025
Severe leptospirosis with unusual manifestation
Norlijah Othman1, H I Intan, C W Yip
1Faculty of Medicine and Health Sciences, University Putra Malaysia, Malaysia. nor@medic.upm.edu.my
Journal of Tropical Pediatrics
|January 24, 2007
Summary
Aboriginal boy with respiratory issues and skin rash was diagnosed with leptospirosis. This infection caused acquired ichthyosis and disseminated intravascular coagulopathy.
Area of Science:
- Pediatrics
- Infectious Diseases
- Dermatology
Background:
- Leptospirosis is a zoonotic infection with diverse clinical manifestations.
- Early diagnosis and treatment are crucial for managing severe leptospirosis.
Observation:
- An 8-year-old Aboriginal boy presented with respiratory insufficiency and widespread skin eruptions.
- The patient exhibited acquired ichthyosis and a non-bleeding form of disseminated intravascular coagulopathy.
- Chest radiography revealed bilateral perihilar opacities and pleural effusion.
Findings:
- Leptospirosis was confirmed through a significant rise in microagglutinating antibody titers and positive PCR results.
- The case highlights unusual dermatological and hematological complications of leptospirosis.
Implications:
- This case underscores the importance of considering leptospirosis in pediatric patients with respiratory and dermatological symptoms.
- Recognizing atypical presentations of leptospirosis is vital for timely intervention and improved patient outcomes.
- Further research into the pathogenesis of acquired ichthyosis and coagulopathy in leptospirosis may be warranted.
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