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Related Concept Videos

Role of Matrix Metalloproteases in Degradation of ECM01:23

Role of Matrix Metalloproteases in Degradation of ECM

Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult body.
A...
The Extracellular Matrix01:42

The Extracellular Matrix

In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.Composition of the Extracellular MatrixThe extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse molecules.
The Extracellular Matrix01:29

The Extracellular Matrix

Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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Related Experiment Video

Updated: Jul 17, 2026

Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis
07:52

Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis

Published on: December 21, 2014

Matrix metalloproteinases in lung: multiple, multifarious, and multifaceted.

Kendra J Greenlee1, Zena Werb, Farrah Kheradmand

  • 1Departments of Medicine and Immunology, Baylor College of Medicine, Houston, Texas, USA.

Physiological Reviews
|January 24, 2007
PubMed
Summary

Matrix metalloproteinases (MMPs) are crucial for lung development but are downregulated post-alveologenesis. Their resurgence in lung inflammation highlights complex roles and potential therapeutic targets.

Related Experiment Videos

Last Updated: Jul 17, 2026

Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis
07:52

Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis

Published on: December 21, 2014

Area of Science:

  • Biochemistry
  • Cell Biology
  • Pulmonary Medicine

Background:

  • Matrix metalloproteinases (MMPs) are a family of neutral proteinases involved in processing extracellular and cell surface proteins.
  • MMPs are vital for lung organogenesis but typically downregulated after alveolar development.
  • Their expression increases during inflammatory lung diseases, indicating a resurgence.

Purpose of the Study:

  • To review the expanding knowledge on MMP resurgence in inflammatory lung diseases.
  • To explore the role of MMP proteolysis in modulating substrate function in vivo.
  • To discuss the implications of MMP redundancy and their potential as therapeutic targets.

Main Methods:

  • Literature review of MMP expression and function in lung biology and disease.
  • Analysis of known and potential MMP substrates in the lung extracellular matrix and cell surface.
  • Discussion of MMP redundancy and compensatory mechanisms.

Main Results:

  • Many MMPs are upregulated during acute and chronic inflammatory lung diseases.
  • Potential MMP targets include extracellular matrix proteins, adhesion molecules, growth factors, cytokines, and chemokines.
  • MMP redundancy likely evolved as a compensatory mechanism due to their critical regulatory importance.

Conclusions:

  • A deeper understanding of MMP biology is necessary before considering MMP inhibition as a therapeutic strategy for lung conditions.
  • The complex roles of MMPs in lung inflammation warrant further investigation.
  • MMPs represent critical regulatory enzymes in lung homeostasis and disease.