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Sweat test in asthmatic children; a single center study

Bahram Mirsaeid Ghazi1, Roya Khalesi, Mohsen Naseri

  • 1Department of Pediatrics, Bahrami Children Hospital, Tehran University of Medical Sciences, Tehran, Iran. bahrami_ch@yahoo.com

Iranian Journal of Allergy, Asthma, and Immunology
|January 24, 2007
PubMed

Insights

A positive sweat test, indicating Cystic Fibrosis (CF), was found in 26% of asthmatic children. This suggests screening asthmatic children with specific symptoms for CF is crucial.

Area of Science:

  • Pediatrics
  • Pulmonology
  • Genetics

Background:

  • Asthma and Cystic Fibrosis (CF) share overlapping clinical manifestations.
  • The diagnostic utility of sweat testing in asthmatic children requires further investigation.

Purpose of the Study:

  • To determine the frequency of positive sweat tests in pediatric asthma patients.
  • To identify clinical indicators associated with a positive sweat test in this cohort.

Main Methods:

  • A cross-sectional study involving 135 asthmatic children at Bahrami Children Hospital, Tehran.
  • All participants underwent sweat testing.
  • Data collection included clinical signs, symptoms, and asthma duration.

Main Results:

  • A positive sweat test was observed in 26% (35/135) of asthmatic children.
  • Positive sweat tests correlated significantly with recurrent respiratory infections, chronic diarrhea, and failure to thrive.
  • Children with positive tests had a longer mean asthma duration (49.3 months) compared to those with negative tests (18.1 months).

Conclusions:

  • The sweat test is a valuable screening tool for Cystic Fibrosis in asthmatic children presenting with specific symptoms.
  • Consider sweat testing for asthmatic children with recurrent respiratory infections, chronic diarrhea, failure to thrive, and prolonged asthma duration.

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