Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Local and systemic hemostasis in surgery].

W O Bechstein1, C Strey

  • 1Klinik für Allgemein- und Gefässchirurgie, Klinikum der Johann-Wolfgang-Goethe-Universität, 60590 Frankfurt am Main. wolf.bechstein@kgu.de

Der Chirurg; Zeitschrift Fur Alle Gebiete Der Operativen Medizen
|January 24, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preoperative portal vein or portal and hepatic vein embolization: DRAGON collaborative group analysis.

The British journal of surgery·2021
Same author

R0 resection following chemo (radio)therapy improves survival of primary inoperable pancreatic cancer patients. Interim results of the German randomized CONKO-007± trial.

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]·2020
Same author

[Procurement of abdominal organs].

Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen·2020
Same author

Consensus on definition and severity grading of lymphatic complications after kidney transplantation.

The British journal of surgery·2020
Same author

Consensus in determining the resectability of locally progressed pancreatic ductal adenocarcinoma - results of the Conko-007 multicenter trial.

BMC cancer·2019
Same author

Secondary technical resectability of colorectal cancer liver metastases after chemotherapy with or without selective internal radiotherapy in the randomized SIRFLOX trial.

The British journal of surgery·2019
Same journal

[S3 Guideline "Adult soft tissue sarcomas"].

Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen·2022
Same journal

[Synopsis-S3 guidelines pancreatic cancer].

Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen·2022
Same journal

[Laparoscopic sentinel node navigation surgery in gastric cancer to reduce surgical radicality].

Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen·2022
Same journal

[Future concepts for neoadjuvant and adjuvant treatment of (resectable) pancreatic cancer].

Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen·2022
Same journal

[ASCO guidelines for the treatment of stage III NSCLC part 4: indications for adjuvant therapy].

Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen·2022
Same journal

[Surgical treatment of pancreatic cancer-What is new?]

Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen·2022
See all related articles

Surgical bleeding is managed with local agents like fibrin sealants and systemic drugs such as tranexamic acid. Evidence from randomized controlled trials guides their use in reducing blood loss and complications.

Area of Science:

  • Surgical hemostasis and bleeding management.
  • Pharmacological interventions in surgery.

Background:

  • Surgical procedures inherently involve bleeding, necessitating effective hemostasis.
  • Hemostasis strategies aim to minimize blood loss, transfusion requirements, and surgical complications like rebleeding and hematoma formation.

Purpose of the Study:

  • To review the evidence for various hemostatic agents used in surgery.
  • To evaluate the efficacy of local and systemic hemostatic agents.

Main Methods:

  • Review of evidence from randomized controlled trials (RCTs).
  • Analysis of data on local hemostatic agents (e.g., fibrin sealants, collagen fleece).
  • Assessment of systemic hemostatic agents (e.g., lysine analogs, aprotinin).

Main Results:

Related Experiment Videos

  • Evidence exists for fibrin sealants, alone or with collagen fleece, from RCTs.
  • Conflicting evidence is noted for systemic fibrinolysis inhibitors like epsilon-aminocaproic acid and tranexamic acid.
  • The role of recombinant activated factor VII is under investigation.

Conclusions:

  • Various local agents are available for surgical hemostasis.
  • Systemic agents targeting fibrinolysis have evidence, though sometimes conflicting.
  • Ongoing research explores novel agents like recombinant activated factor VII.