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Applications of Liquid-Chromatography Tandem Mass Spectrometry in Natural Products Research: Tropane Alkaloids as a Case Study
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Naturally occurring rearranged taxoids.

B Das1, S P Rao, R D Née Chakrabarti

  • 1Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad 500007, India.

Planta Medica
|October 1, 1995
PubMed
Summary

Rearranged taxoids from Taxus species are increasingly reported. This review covers their chemistry, origin, and biological activity.

Area of Science:

  • Natural Product Chemistry
  • Phytochemistry
  • Organic Chemistry

Background:

  • Taxus species are a rich source of complex polyoxygenated diterpenoids known as taxoids.
  • Rearranged taxoids represent a significant subclass with unique structural features.
  • Recent discoveries highlight the diversity and prevalence of these compounds across various Taxus species.

Purpose of the Study:

  • To provide a comprehensive review of rearranged taxoids from Taxus species.
  • To consolidate information on the chemical structures, biosynthesis, and bioactivity of these compounds.
  • To highlight recent advancements in the field.

Main Methods:

  • Literature review of scientific databases (e.g., PubMed, Scopus, Web of Science).
  • Analysis of published research on the isolation, characterization, and biological evaluation of rearranged taxoids.

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  • Synthesis of information regarding biosynthetic pathways and structure-activity relationships.

    • Main Results:

    • An increasing number of rearranged taxoid structures have been identified from diverse Taxus species.
    • Key chemical transformations and biosynthetic routes leading to these complex molecules have been elucidated.
    • A wide spectrum of biological activities, including cytotoxic and antitumor properties, has been associated with these compounds.

    Conclusions:

    • Rearranged taxoids are a promising class of natural products with significant therapeutic potential.
    • Further research into their biosynthesis and bioactivity could lead to the development of novel pharmaceuticals.
    • Continued exploration of Taxus species is crucial for discovering new and potentially valuable taxoids.