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Updated: Jul 17, 2026

Navigating the Mass Spectrometry-Based Proteomic Data Using Free Computational Tools
Published on: August 19, 2025
A new approach for the analysis of mass spectrometry data for biomarker discovery
N Barbarini1, P Magni, R Bellazzi
1Department of Computer Science and Systems, University of Pavia, Italy. nicola.barbarini01@ateneopv.it
Abstract:
In the last few years a growing interest has been devoted to disease diagnosis based on proteomic profiles of body fluids generated by mass spectrometry. In this work, we will present a new approach for their analysis for biomarker discovery. In particular, we will describe a new strategy for the analysis of SELDI/MALDI-TOF serum data based on the following three steps: i) data-preprocessing, ii) feature (mass/charge ratio, m/z) reduction and selection, iii) association of the selected features to a list of compatible known proteins. The method is applied to an ovarian cancer dataset.
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