Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Longitudinal Research02:20

Longitudinal Research

Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
Pharmacovigilance01:19

Pharmacovigilance

Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
Longitudinal Studies01:26

Longitudinal Studies

Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
Long-term Depression01:05

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Natural killer/T cell lymphoma initiating with pleural effusion: the significance of MICM combined techniques for the diagnosis.

Zhongguo shi yan xue ye xue za zhi·2009
Same author

[Advance of study on animal models of lymphoma].

Zhongguo shi yan xue ye xue za zhi·2009
Same author

[Pharmaceutical care of patient with cryptococcal meningitis: a case report].

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences·2009
Same author

[Identification and genetic analysis of pale-green mutant caused by Ds insertion in rice].

Yi chuan = Hereditas·2009
Same author

Purification and characterization of a Laccase with inhibitory activity toward HIV-1 reverse transcriptase and tumor cells from an edible mushroom (Pleurotus cornucopiae).

Protein and peptide letters·2009
Same author

Effect of Chinese herbal treatment on Th1- and Th2-type cytokines, progesterone and beta-human chorionic gonadotropin in early pregnant women of threatened abortion.

Chinese journal of integrative medicine·2009

Related Experiment Video

Updated: Jul 17, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

askMEDLINE: a report on a year-long experience.

Paul Fontelo1, Fang Liu, Michael Ackerman

  • 1Office of High Performance Computing and Communications, National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20894, USA.

AMIA ... Annual Symposium Proceedings. AMIA Symposium
|January 24, 2007
PubMed
Summary

askMEDLINE, a natural language search tool for MEDLINE/PubMed, has processed over 15,000 queries in its first year. Therapy-related questions were the most frequent search topic, indicating user interest in treatment information.

Related Experiment Videos

Last Updated: Jul 17, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

Area of Science:

  • Medical Informatics
  • Biomedical Literature Search

Background:

  • MEDLINE/PubMed is a primary resource for biomedical literature.
  • Efficiently searching large databases like MEDLINE/PubMed can be challenging for users.
  • Natural language processing (NLP) offers potential for improved search functionality.

Purpose of the Study:

  • To review the first year of askMEDLINE, a free-text, natural language search tool for MEDLINE/PubMed.
  • To evaluate the performance of askMEDLINE using expert-selected 'gold standard' questions.
  • To discuss enhancements and features added to the askMEDLINE tool.

Main Methods:

  • Analysis of over 15,000 queries received by askMEDLINE in its first year.
  • Updated evaluation using 'gold standard' questions curated by Evidence-Based Medicine (EBM) experts.
  • Review of user query patterns, focusing on the types of questions asked.

Main Results:

  • askMEDLINE received more than 15,000 queries in its initial year.
  • The majority of queries were in the form of questions or complex phrases.
  • Questions pertaining to therapy were the most commonly searched topic.

Conclusions:

  • askMEDLINE demonstrates utility as a natural language search interface for MEDLINE/PubMed.
  • User query data highlights a significant interest in therapeutic information.
  • Ongoing development and evaluation are crucial for optimizing search tool performance.