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Implementing daily dosing rules using a commercial rule base.

Ervina Resetar1, Richard M Reichley, Laura A Noirot

  • 1Washington University School of Medicine, Department of Internal Medicine, St. Louis, MO, USA.

AMIA ... Annual Symposium Proceedings. AMIA Symposium
|January 24, 2007
PubMed
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We refined the DoseRanger pharmacy expert system to reduce unnecessary alerts by adjusting single dosage rules. Similar adjustments are needed for daily dosage rules to improve clinical relevance.

Area of Science:

  • Clinical Informatics
  • Pharmaceutical Sciences
  • Health Systems Pharmacy

Background:

  • Pharmacy expert systems aid in medication safety.
  • The DoseRanger system previously addressed single dosage alerts.
  • Clinically insignificant alerts can reduce system utility.

Purpose of the Study:

  • To evaluate rule adjustments for daily dosage rules in the DoseRanger system.
  • To reduce clinically insignificant alerts generated by daily dosage rules.
  • To determine if similar techniques used for single dosage rules are applicable to daily dosage rules.

Main Methods:

  • Analysis of daily dose rules from a commercial rule base.
  • Evaluation of rule adjustments to minimize clinically insignificant alerts.

Related Experiment Videos

  • Comparison of techniques with prior single dosage rule analysis.

    • Main Results:

    • A similar analysis was performed for daily dose rules.
    • The analysis demonstrated the need for analogous techniques.
    • Rule adjustments are likely necessary for daily dosage optimization.

    Conclusions:

    • Techniques used to reduce single dosage alerts are applicable to daily dosage rules.
    • Further refinement of the DoseRanger system is required for daily dosage.
    • Optimizing daily dosage rules will enhance the clinical utility of the pharmacy expert system.