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Non-rash skin toxicities associated with novel targeted therapies

Mario E Lacouture1, Scott A Boerner, Patricia M Lorusso

  • 1Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL 48201, USA.

Clinical Lung Cancer
|January 24, 2007
PubMed

Insights

Novel targeted cancer therapies can cause non-rash skin toxicities like hyperpigmentation and xerosis, impacting treatment. Early recognition and management of these side effects are crucial for continuing anticancer therapy.

Area of Science:

  • Oncology
  • Dermatology

Background:

  • Targeted anticancer agents are increasingly used for various malignancies.
  • Papulopustular rash is a common side effect, but other dermatologic toxicities also occur.

Purpose of the Study:

  • To review non-rash dermatologic toxicities associated with targeted therapeutic agents.
  • To provide guidelines for the diagnosis and treatment of these toxicities.

Main Methods:

  • Literature review of non-rash skin toxicities from targeted agents.
  • Analysis of reported toxicities including hyperpigmentation, xerosis, pruritus, hair changes, nail changes, and hand-foot skin reaction.

Main Results:

  • Several non-rash skin toxicities frequently lead to treatment delay or discontinuation.
  • Key toxicities include skin hyperpigmentation, xerosis, pruritus, hair abnormalities, nail alterations, and hand-foot skin reaction.

Conclusions:

  • Non-rash dermatologic toxicities are significant side effects of targeted cancer therapies.
  • Early diagnosis and appropriate management are essential to prevent treatment interruption.

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