Synthesis and cytotoxicity of novel fatty acid-nucleoside conjugates
Yun-Xiao Zhang1, Gui-Fu Dai, Le Wang
1Department of Chemistry, New Drug Research & Development Center, Zhengzhou University, Zhengzhou 450052, PR China.
Bioorganic & Medicinal Chemistry Letters
|January 24, 2007
Abstract:
N(3)-Hydroxyethyltegafur (3) was synthesized in 91.0% yield under a new condition. A series of novel fatty acid esters of 3 were synthesized. These fatty acid-nucleoside conjugates have shown cytotoxicities against Ec9706 cells and A549 cells, and the structure activity relationship was discussed.
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