Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genetics of ischaemic stroke.

Martin Dichgans1

  • 1Department of Neurology, Neurologische Klinik, Klinikum Grosshadern, Ludwig-Maximilians-University, D-81377 München, Germany. martin.dichgans@med.uni-muenchen.de

The Lancet. Neurology
|January 24, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Single-cell transcriptome-wide Mendelian randomization and colocalization analyses uncover cell-specific mechanisms in atherosclerotic cardiovascular disease.

American journal of human genetics·2025
Same author

Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations.

Nature genetics·2025
Same author

<i>APOE</i> stratified genome-wide association studies provide novel insights into the genetic etiology of Alzheimers's disease.

medRxiv : the preprint server for health sciences·2025
Same author

Reduced myelin contributes to cognitive impairment in patients with monogenic small vessel disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Immunothrombolytic monocyte-neutrophil axes dominate the single-cell landscape of human thrombosis and correlate with thrombus resolution.

Immunity·2025
Same author

The relation between cerebral small vessel function and white matter microstructure in monogenic and sporadic small vessel disease - the ZOOM@SVDs study.

Cerebral circulation - cognition and behavior·2025

Genetic factors contribute to ischaemic stroke risk, with single genes like NOTCH3 and complex gene interactions playing roles. Identifying more genes is crucial for understanding and treating this multifactorial disorder.

Area of Science:

  • Genetics
  • Neurology
  • Epidemiology

Background:

  • Ischaemic stroke is a complex, multifactorial disease with a known genetic predisposition.
  • Progress has been made in understanding single-gene causes, like NOTCH3 mutations in CADASIL.
  • The role of genetics in multifactorial stroke risk and prediction remains largely unknown.

Purpose of the Study:

  • To explore the genetic underpinnings of ischaemic stroke.
  • To identify genes and pathways contributing to stroke risk.
  • To advance the understanding of genetic predisposition in ischaemic stroke.

Main Methods:

  • Review of genetic association studies and genome-wide linkage studies.
  • Analysis of candidate pathways including haemostatic, inflammatory, and metabolic systems.

Related Experiment Videos

  • Leveraging advances in high-throughput genotyping and biostatistics for genome-wide association studies (GWAS).

    • Main Results:

    • NOTCH3 mutations linked to CADASIL offer insights into small-vessel disease.
    • Studies highlight the importance of modifier genes and gene-gene interactions (e.g., sickle-cell disease).
    • Specific haplotypes in PDE4D and ALOX5AP identified in Icelandic populations, with unclear generalizability.

    Conclusions:

    • Genetics plays a significant role in ischaemic stroke, from single-gene disorders to multifactorial influences.
    • Identifying numerous small-effect alleles is key to understanding complex stroke.
    • Collaborative GWAS are essential for discovering new genes, pathways, and therapeutic targets for ischaemic stroke.