Changes in measured endometrial thickness predict in vitro fertilization success

Area of Science:

• Reproductive Endocrinology
• Ultrasound in Medicine
• In Vitro Fertilization

Background:

• Endometrial receptivity is crucial for successful implantation.
• Assessing endometrial thickness is a common practice in IVF protocols.
• Predictive markers for IVF success are continuously sought.

Purpose of the Study:

• To evaluate the predictive value of endometrial thickness and its dynamic changes for pregnancy outcomes in IVF patients.
• To determine optimal endometrial thickness thresholds for implantation and pregnancy.

Main Methods:

• Retrospective cohort analysis of 132 fresh autologous IVF cycles.
• Transvaginal ultrasound measurements of endometrial thickness at three key time points: post-suppression, day 6 of stimulation, and hCG administration day.
• Analysis of endometrial thickness at baseline, day 6, hCG day, and the change during stimulation.

Main Results:

• Pregnant patients exhibited significantly greater endometrial thickness on day 6 and hCG administration day.
• A more pronounced increase in endometrial thickness from baseline to day 6 was observed in pregnant patients.
• Receiver-operator characteristic curve analysis identified significant endometrial thickness levels predictive of implantation and pregnancy rates.

Conclusions:

• Endometrial responsiveness and thickness during early IVF stimulation are superior prognostic indicators of IVF success.
• Dynamic changes in endometrial thickness offer greater predictive power than static measurements at cycle initiation or completion.