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Related Experiment Video

Updated: Jul 17, 2026

Establishment of a Rat Model of Superior Sagittal-Sinus Occlusion via a Thread-Embolism Method
08:07

Establishment of a Rat Model of Superior Sagittal-Sinus Occlusion via a Thread-Embolism Method

Published on: July 4, 2021

Cerebral venous sinus thrombosis: developing an experimental model.

Amit Kumar Srivastava1, Rakesh Kumar Gupta, Mohamad Haris

  • 1Department of Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareily Road, Lucknow 226014, India.

Journal of Neuroscience Methods
|January 24, 2007
PubMed
Summary

Researchers developed a simple rat model for cerebral venous sinus thrombosis using ferric chloride. This model reliably induces thrombosis, showing T2 hyperintensity on MRI in all subjects and TTC staining changes in 50%.

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Area of Science:

  • Neuroscience
  • Experimental Medicine
  • Animal Models

Background:

  • Cerebral venous sinus thrombosis (CVST) is a significant neurological condition.
  • Developing reliable experimental models is crucial for understanding CVST pathophysiology.
  • Existing models may lack simplicity or reproducibility.

Purpose of the Study:

  • To establish a straightforward and reproducible animal model for inducing cerebral venous sinus thrombosis in rats.
  • To validate the model's efficacy using MRI and post-mortem histological analysis.

Main Methods:

  • A cranial window was created to expose the superior sagittal sinus (SSS) in Sprague-Dawley rats.
  • Ferric chloride solution was applied topically to induce SSS thrombosis in the experimental group.

Related Experiment Videos

Last Updated: Jul 17, 2026

Establishment of a Rat Model of Superior Sagittal-Sinus Occlusion via a Thread-Embolism Method
08:07

Establishment of a Rat Model of Superior Sagittal-Sinus Occlusion via a Thread-Embolism Method

Published on: July 4, 2021

  • Magnetic Resonance Imaging (MRI) and 2,3,5-triphenyltetrazolium chloride (TTC) staining were used for assessment.

    • Main Results:

    • All experimental rats (9/9) exhibited T2 hyperintense lesions on MRI, indicative of thrombosis.
    • Histological analysis (TTC staining) revealed changes in 50% of experimental rats (7/14).
    • No significant differences were observed in rota rod studies between experimental and control groups.

    Conclusions:

    • The ferric chloride-induced SSS thrombosis model in rats is simple and effective.
    • The model demonstrates high sensitivity for detecting thrombosis via MRI.
    • This model provides a valuable tool for future research into cerebral venous sinus thrombosis.