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Related Concept Videos

Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
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Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

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Phosphoinositides and PIPs01:42

Phosphoinositides and PIPs

Phosphoinositides are a group of phospholipids containing a glycerol backbone with two fatty acid chains and a phosphate attached to a myoinositol sugar ring. The inositol head group extends into the cytoplasm, where it is modified by adding phosphate groups to form phosphatidylinositol phosphates or PIPs.
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...
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Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
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Rh Blood Group

The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.

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Related Experiment Video

Updated: Jul 17, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

The obstetric antiphospholipid syndrome.

R H W M Derksen1, Ph G de Groot

  • 1Department of Rheumatology and Clinical Immunology, University Medical Center, Utrecht, The Netherlands. r.h.w.m.derksen@umcutrecht.nl

Journal of Reproductive Immunology
|January 24, 2007
PubMed
Summary

Antiphospholipid syndrome, linked to blood clots and pregnancy loss, requires careful management. Optimal treatment during pregnancy improves live birth rates to 70-80%.

Area of Science:

  • Obstetrics and Gynecology
  • Rheumatology
  • Hematology

Background:

  • Antiphospholipid syndrome (APS) is characterized by persistent antiphospholipid antibodies, leading to thromboembolic events or pregnancy complications.
  • Pregnancies in women with APS are considered high-risk, necessitating specialized care.
  • Understanding APS pathophysiology is crucial for effective management.

Purpose of the Study:

  • This review focuses on the management and treatment of antiphospholipid syndrome during pregnancy.
  • To highlight the importance of early diagnosis and intervention for high-risk pregnancies.
  • To provide insights into achieving better pregnancy outcomes in women with APS.

Main Methods:

  • Review of current literature on antiphospholipid syndrome diagnosis and management.

Related Experiment Videos

Last Updated: Jul 17, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

  • Focus on pharmacological treatments and close monitoring strategies for pregnant patients.
  • Analysis of factors influencing pregnancy outcomes in women with APS.

    • Main Results:

    • Optimal management, including close follow-up and pharmacological treatment, can achieve live birth rates of 70-80%.
    • Early diagnosis based on laboratory findings and clinical criteria is essential.
    • Specific treatment protocols during pregnancy significantly mitigate risks.

    Conclusions:

    • Antiphospholipid syndrome poses significant risks during pregnancy, but outcomes can be improved.
    • Effective management strategies are key to increasing live birth rates in affected women.
    • Continued research into APS pathophysiology and treatment is vital for optimizing patient care.