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Related Experiment Videos

B cell mediated priming following pneumococcal colonization.

Bradley Rabquer1, Anne K Shriner, S Louise Smithson

  • 1Department of Medicine, University of Toledo-Health Science Campus, Health Education Building, 3055 Arlington Ave., Toledo, OH 43614, United States.

Vaccine
|January 24, 2007
PubMed
Summary
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Pneumococcal colonization primes the immune system, stimulating memory B cell production. This enhances the immune response to subsequent pneumococcal conjugate vaccine (CPV) vaccination.

Area of Science:

  • Immunology
  • Microbiology
  • Vaccinology

Background:

  • Streptococcus pneumoniae colonizes the human nasopharynx, initiating pathogenesis.
  • Pneumococcal colonization has been shown to prime the immune response to pneumococcal conjugate vaccine (CPV).

Purpose of the Study:

  • To determine if pneumococcal colonization stimulates the production of memory B cells that are activated by CPV vaccination.

Main Methods:

  • Mice were colonized with Streptococcus pneumoniae serotype 14.
  • B cells and CD4+ T cells from colonized mice were adoptively transferred to naive recipients.
  • Recipients were vaccinated with CPV.

Main Results:

  • Pneumococcal colonization stimulates the production of memory B cells.

Related Experiment Videos

  • These memory B cells enhance the immune response following CPV vaccination.

    • Conclusions:

    • Pneumococcal colonization induces a memory B cell population.
    • This memory B cell population plays a crucial role in augmenting the immune response to CPV vaccination.