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Malignant peripheral primitive neuroectodermal (pPNET) of tongue.
Cuneyt Ulutin1, Oguz Cetinayak, Gorkem Aksu
1Gulhane Military Faculty of Medicine, Radiation Oncology Department, Turkey.
Auris, Nasus, Larynx
|January 24, 2007
Summary
This study details a rare oral Primitive Neuroectodermal Tumor (PNET) on the tongue. Despite treatment, the patient developed liver metastases and survived for 10 months post-chemotherapy.
Area of Science:
- Oncology
- Pathology
- Medical Case Reports
Background:
- Primitive Neuroectodermal Tumors (PNETs) are rare neoplasms.
- PNETs encompass tumors previously classified as Ewing's sarcoma.
- Peripheral neuroepithelioma is a synonym for PNET.
Observation:
- A unique case of PNET originating in the oral cavity, specifically the tongue, is presented.
- This represents the first documented instance of a PNET in this anatomical location in medical literature.
- The patient received standard treatment including postoperative radiotherapy and chemotherapy.
Findings:
- The patient experienced disease progression with multiple liver metastases occurring 5 months post-diagnosis.
- Despite aggressive chemotherapy, the patient's survival was limited to an additional 10 months.
Implications:
- Highlights the potential for PNETs to occur in unusual sites like the oral tongue.
- Underscores the aggressive nature and poor prognosis associated with advanced PNETs, even with multimodal treatment.
- Suggests the need for vigilance in diagnosing and managing rare PNET presentations.
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