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Is Her-2/neu expressed in nonepithelial ovarian malignancies?
Joseph Menczer1, Letizia Schreiber, Bernard Czernobilsky
1Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, E. Wolfson Medical Center, Holon, Israel.
Objective:
The objective of this study was to assess the expression of Her-2/neu in nonepithelial ovarian malignancies.
Study Design:
Formalin-fixed paraffin-embedded archival tissue blocks of 20 unselected nonepithelial ovarian malignancies (12 granulosa cell tumors and 8 germ cell tumors) diagnosed between 1993 and 2005 were immunohistochemically stained for Her-2/neu.
Results:
Immunohistochemical staining for Her-2/neu was not present in any of these nonepithelial malignancies examined.
Conclusion:
Our limited sample size does not allow a generalized conclusion concerning the lack of Her-2/neu expression in nonepithelial ovarian malignancies, but it adds information with regard to the expression of this oncogene in these rare neoplasms and seems to indicate that it is not a frequent occurrence.

