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Metastasizing dermatofibroma in lung
MiJin Gu1, KyungRak Sohn, DongJa Kim
1Department of Pathology, Daegu Fatima Hospital, Daegu 701-600, Korea. gmjap@fatima.or.kr
Annals of Diagnostic Pathology
|January 24, 2007
Summary
Metastatic dermatofibroma, a rare event, was diagnosed in a 36-year-old woman with multiple lung nodules. Histologic analysis confirmed the lung masses shared features with the original skin lesion, indicating metastasis.
Area of Science:
- Oncology
- Dermatology
- Pathology
Background:
- Dermatofibroma is a common benign skin neoplasm.
- Metastasis from dermatofibroma is exceedingly rare.
Observation:
- A 36-year-old woman presented with multiple bilateral lung nodules.
- A history of cellular dermatofibroma of the right shoulder, biopsied 7 years prior, was noted.
Findings:
- Chest CT revealed multiple pulmonary nodules.
- Surgical resection showed hemorrhagic cysts with dilated cystic airspaces lined by respiratory and metaplastic squamous epithelium.
- Underlying fibrohistiocytic spindle cells stained positive for CD68 and CD10, consistent with the original skin lesion.
Implications:
- This case highlights the rare possibility of dermatofibroma metastasis.
- Accurate histologic and immunohistochemical evaluation is crucial for diagnosing metastatic potential.
- Understanding rare metastatic patterns aids in patient management and prognosis.
