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Updated: Jul 17, 2026

Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody (mAb) by Neutralizing TNF Using an In Vitro Bioanalytical Method
Published on: September 16, 2017
[Anti TNF-alpha treatment of a refractory polymyositis]
D Wendling1, C Prati, P Ornetti
1Service de Rhumatologie, CHU Jean-Minjoz, boulevard Fleming, 25030 Besançon cedex, France. daniel.wendling@ufc-chu.univ-fcomte.fr
Introduction:
Anti TNF-alpha agents may represent a possibility of treatment in cases of refractory polymyositis.
Case Report:
We report a case of polymyositis refractory to corticosteroids and immunosuppressive agents in whom adjunction of infliximab led to a mild and transient improvement, and a secondary improvement after discontinuation of the treatment.
Discussion:
In the reported cases of polymyositis treated with infliximab or etanercept a short-term response was seen in 9 out of 11 cases. Adverse events of the treatment are mentioned, and should be taken into account in the decision of treatment.
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