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Related Concept Videos

Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
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T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
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Pulmonary Tuberculosis I01:29

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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
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Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

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Cytotoxic T Cells-mediated Immune Response01:27

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Related Experiment Video

Updated: Jul 17, 2026

Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix
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Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix

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Decrease in CD4+ T lymphocyte proliferation responses and enhanced CD150 cell expression in health care workers

Nirupma Trehan Pati1, Sukriti, Syed Hissar

  • 1Department of Gastroenterology, G.B. Pant Hospital, New Delhi, India.

Vaccine
|January 24, 2007
PubMed
Summary

Non-response to hepatitis B vaccine is common in healthcare workers. Enhanced CD150 expression on T cells correlates with weak cellular proliferation, potentially predicting vaccine unresponsiveness.

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Published on: February 28, 2019

Area of Science:

  • Immunology
  • Vaccinology
  • Molecular Biology

Background:

  • Hepatitis B vaccine unresponsiveness affects 5-40% of healthcare workers (HCWs).
  • The cellular and molecular mechanisms of HBV vaccine unresponsiveness remain poorly understood.

Purpose of the Study:

  • To investigate CD150 surface expression in relation to cellular proliferation in hepatitis B vaccine responders and non-responders.
  • To identify potential cellular markers associated with non-responsiveness to HBV vaccination.

Main Methods:

  • Gene chip analysis to identify differentially expressed markers.
  • Flow cytometry to assess CD150 surface expression on T cells.
  • In vitro cell proliferation assays using polyclonal and HBV-specific stimulation.

Main Results:

  • CD150 was identified as an upregulated marker on activated T cells, associated with suppressive regulatory cell function.
  • Non-responders exhibited significantly weaker cellular proliferation compared to responders.
  • Enhanced CD150 surface expression was significantly associated with reduced cellular proliferation in non-responders.

Conclusions:

  • Elevated CD150 expression on T cells is linked to impaired cellular proliferation.
  • CD150 upregulation may serve as a predictive biomarker for hepatitis B vaccine non-responsiveness in HCWs.