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Effect of exercise intensity on active and passive glucose absorption
James A Lang1, Carl V Gisolfi, G Patrick Lambert
1Dept of Exercise Science and Athletic Training, Creighton University, Omaha, NE 68178, USA.
International Journal of Sport Nutrition and Exercise Metabolism
|January 24, 2007
Summary
High-intensity exercise, specifically running at 70% VO2max, significantly reduces both active and passive intestinal glucose absorption in trained runners. This finding suggests altered nutrient uptake during intense physical activity.
Area of Science:
- Exercise Physiology
- Gastroenterology
- Nutritional Science
Background:
- Intestinal glucose absorption is crucial for energy supply during exercise.
- The impact of varying exercise intensities on both active and passive glucose absorption mechanisms remains incompletely understood.
Purpose of the Study:
- To investigate the effects of different exercise intensities on active and passive intestinal glucose absorption.
- To determine if high-intensity exercise impairs glucose uptake in trained athletes.
Main Methods:
- Eight trained runners completed a resting trial and three 1-hour treadmill trials at 30%, 50%, and 70% VO2max.
- Subjects ingested non-metabolizable glucose analogs: 3-O-methyl-D-glucose (active) and D-xylose (passive).
- Urinary excretion of glucose analogs was measured over 5 hours to quantify absorption.
Main Results:
- A significant reduction (P < 0.05) in urinary excretion of both 3-O-methyl-D-glucose and D-xylose was observed at 70% VO2max compared to rest, 30%, and 50% VO2max.
- This indicates a decrease in both active and passive intestinal glucose absorption at the highest exercise intensity.
- No significant differences were noted between resting, 30%, and 50% VO2max conditions.
Conclusions:
- Prolonged running at 70% VO2max significantly impairs intestinal glucose absorption, affecting both active and passive transport mechanisms.
- Athletes engaging in high-intensity endurance activities may experience reduced nutrient absorption.
- Further research is warranted to explore the physiological mechanisms behind this reduced absorption and its implications for performance and hydration.
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