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Updated: Jul 17, 2026
05:45
Diagnosis of Hirschsprung's Disease by Immunostaining Rectal Suction Biopsies for Calretinin, S100 Protein and Protein Gene Product 9.5
Published on: April 26, 2019
[Hirschsprung disease: lessons learned from the last 100 cases]
L A Luis1, J L Encinas, L F Avila
1Departamento de Cirugía Pediátrica, Hospital Universitario La Paz, Madrid.
Summary
This study compared 100 Hirschsprung's disease (HD) patients treated between 1992-2004. Key differences included earlier definitive treatment, reduced stoma use, and more transanal procedures in the later period, with good continence outcomes.
Area of Science:
- Pediatric Surgery
- Gastroenterology
- Clinical Medicine
Context:
- Hirschsprung's disease (HD) is a congenital disorder affecting the large intestine.
- Management strategies for HD have evolved over time.
- Comparing outcomes across different treatment periods is crucial for improving patient care.
Purpose:
- To analyze changes in morbidity, mortality, and outcomes for 100 Hirschsprung's disease patients.
- To identify differences in management between two distinct treatment periods (1992-1997 and 1998-2004).
- To evaluate the impact of evolving surgical techniques and management on patient outcomes.
Summary:
- A retrospective analysis of 100 Hirschsprung's disease patients revealed significant changes in management between 1992-1997 and 1998-2004.
- The later period (1998-2004) demonstrated a reduced need for stomas (6% vs. 30%) and a younger median age at definitive operation.
- While enterocolitis remained a concern, overall continence rates were high (86%) and not significantly affected by the treatment period or specific surgical procedure.
Impact:
- The findings highlight the benefits of earlier surgical intervention and less invasive procedures in managing Hirschsprung's disease.
- This study provides valuable insights for optimizing surgical timing and technique selection in pediatric patients with HD.
- Improved management strategies can lead to better long-term outcomes, including enhanced continence and reduced complications.
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