Related Experiment Video
Updated: Jul 17, 2026
Studying Chronic Exposure of Mice to Ultraviolet B Radiation
Published on: August 19, 2025
UV-B irradiation attenuates dermal effects of botulinum toxin A: a randomized, double-blind, placebo-controlled study
Thomas Sycha1, Nicole Kotzailias, Gottfried Kranz
1Department of Neurology, Medical University of Vienna, Vienna, Austria. thomas.sycha@meduniwien.ac.at
Background:
Botulinum toxin type A (BoNT/A) is frequently used for cosmetic indications and hyperhidrosis.
Objectives:
We investigated whether UV-B irradiation alleviates the BoNT/A effect on local sudomotor activity.
Materials And Methods:
In a randomized, double-blinded trial, the anhidrotic areas after BoNT/A (100 mU) injection 48 hours before and 14 days after UV-B irradiation were compared in six healthy volunteers.
Results:
UV-B irradiation alleviated BoNT/A effect by approximately 30% (p=.0017). The UV-B-evoked reduction of anhidrotic areas was constant over the observation period of 14 weeks.
Conclusions:
When BoNT/A is applied intradermally, excessive exposure to UV-B and sunburn should be reconsidered. The authors have indicated no significant interest with commercial supporters.
Related Concept Videos
01:11Blinding
01:26Directly Acting Muscle Relaxants: Dantrolene and Botulinum Toxin
The binding of dantrolene to the RYR1...