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Does ondansetron or granisetron prevent subarachnoid morphine-induced pruritus after cesarean delivery?
Sahar M Siddik-Sayyid1, Marie T Aouad, Samar K Taha
1Department of Anesthesiology, American University of Beirut Medical center, Beirut, Lebanon. ss01@aub.edu.lb
Background:
We compared the efficacy of granisetron and ondansetron for the prevention of subarachnoid morphine-induced pruritus after cesarean delivery.
Methods:
The incidence of pruritus was assessed in parturients who were randomly allocated into Group G (granisetron 3 mg IV, n = 45), Group O (ondansetron 8 mg IV, n = 42), and Group S (saline IV, n = 42).
Results:
The incidence of pruritus was not significantly different among the 3 groups (86.6% in Group S, 83.3% in Group O, and 88% in the Group G).
Conclusion:
Neither prophylactic ondansetron nor granisetron reduced the incidence of subarachnoid morphine-induced pruritus when compared with the saline group.
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