Related Experiment Video

Updated: Jul 17, 2026

In Vivo Immunofluorescence Localization for Assessment of Therapeutic and Diagnostic Antibody Biodistribution in Cancer Research
08:53

In Vivo Immunofluorescence Localization for Assessment of Therapeutic and Diagnostic Antibody Biodistribution in Cancer Research

Published on: September 16, 2019

Monoclonal antibodies as therapeutic agents in oncology and antibody gene therapy

Qi Zhang1, Guihua Chen, Xinyuan Liu

  • 1Transplantation Research Institute of Sun Yat-sen University, The Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Rd, Guangzhou 510630, China.

Cell Research
|January 24, 2007
PubMed

Insights

Monoclonal antibodies are key cancer treatments, particularly for lymphoma and breast cancer. Research explores enhancing antibody therapy through gene therapy and stem cell delivery for improved anti-tumor efficacy.

Area of Science:

  • Oncology
  • Immunotherapy
  • Biotechnology

Background:

  • Antibodies have become significant therapeutic agents in oncology.
  • Established applications include treatments for lymphoma, breast cancer, and colorectal cancer.

Purpose of the Study:

  • To provide a historical overview of monoclonal antibody development for cancer treatment.
  • To summarize clinical data for established antibody reagents.
  • To discuss novel strategies for enhancing anti-tumor efficacy.

Main Methods:

  • Review of historical development and clinical data of antibody therapies.
  • Exploration of antibody gene therapy as a treatment enhancement strategy.
  • Investigation of mesenchymal stem cells for antibody gene delivery.

Main Results:

  • Monoclonal antibodies are widely used and effective in treating various cancers.
  • Significant clinical data supports the efficacy of established antibody reagents.
  • Emerging strategies show promise for improving therapeutic outcomes.

Conclusions:

  • Antibody therapy is a cornerstone of modern cancer treatment.
  • Future directions involve advanced techniques like gene therapy and stem cell-mediated delivery.
  • Continued research aims to optimize antibody efficacy against tumors.

More Related Videos

Analyzing Tumor and Tissue Distribution of Target Antigen Specific Therapeutic Antibody07:36

Analyzing Tumor and Tissue Distribution of Target Antigen Specific Therapeutic Antibody

Published on: May 16, 2020

Generation of Discriminative Human Monoclonal Antibodies from Rare Antigen-specific B Cells Circulating in Blood13:14

Generation of Discriminative Human Monoclonal Antibodies from Rare Antigen-specific B Cells Circulating in Blood

Published on: February 6, 2018

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Hybridoma Technology01:31

Hybridoma Technology

Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
Hybridoma Selection
Commonly used fusion techniques — electroporation, polyethylene glycol...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...