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In vitro apatite formation on polyamide containing carboxyl groups modified with silanol groups
Takahiro Kawai1, Chikara Ohtsuki, Masanobu Kamitakahara
1Graduate School of Materials Science, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0192, Japan.
Journal of Materials Science. Materials in Medicine
|January 24, 2007
Summary
Modifying organic polymers with silanol groups enhances apatite formation but decreases adhesive strength. This research explores how silanol group content impacts bioactivity and bonding in polymer substrates for biomedical applications.
Area of Science:
- Materials Science
- Biomaterials Engineering
- Polymer Chemistry
Background:
- Organic polymers can be modified to exhibit bioactivity, forming apatite in simulated body fluid (SBF).
- The influence of silanol group modification on apatite formation and adhesion strength on polymer substrates remains unclear.
Purpose of the Study:
- To investigate how varying amounts of silanol groups on polyamide influence apatite formation.
- To assess the effect of silanol group content on the adhesive strength between the polymer and the formed apatite layer.
Main Methods:
- Polyamide films containing carboxyl groups were modified with different concentrations of silanol groups.
- Apatite formation was evaluated using 1.5SBF (1.5 times the ion concentration of SBF).
- Adhesive strength of the apatite layer was measured after exposure and drying.
Main Results:
- Apatite formation rate increased with higher silanol group content in polyamide films, potentially due to enhanced dipole interactions.
- Adhesive strength of the apatite layer tended to decrease as silanol group content increased, possibly due to swelling and shrinkage effects.
Conclusions:
- Modification of organic polymers with silanol groups effectively induces apatite deposition, enhancing bioactivity.
- The concentration of silanol functional groups directly influences both the rate of apatite formation and the adhesion strength of the apatite layer to the polymer substrate.
