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Mean platelet volume in patients with isolated coronary artery ectasia
Atila Bitigen1, Ali Cevat Tanalp, Orhan Hakan Elonu
1Department of Cardiology, Kartal Kosuyolu Heart and Education Hospital, Kartal, Istanbul, Turkey.
Insights
Patients with isolated coronary artery ectasia (CAE) show significantly higher mean platelet volume (MPV), a marker of platelet reactivity. This finding suggests altered platelet function may contribute to ischemic events in CAE patients.
Area of Science:
- Cardiology
- Hematology
- Vascular Biology
Background:
- Coronary artery ectasia (CAE) is often an incidental angiographic finding.
- Emerging evidence links CAE to myocardial ischemia and infarction.
- Platelet reactivity is crucial in cardiovascular events.
Purpose of the Study:
- To investigate platelet function in patients with isolated coronary artery ectasia (CAE).
- To evaluate mean platelet volume (MPV) as a marker of platelet reactivity in isolated CAE.
- To compare MPV and other biochemical markers between isolated CAE patients and controls.
Main Methods:
- A case-control study involving 23 patients with isolated CAE and 30 age- and sex-matched controls with normal coronary arteries.
- Measurement of serum total cholesterol, HDL-C, LDL-C, triglycerides, hemoglobin, white blood cell count, CRP, platelet count, and MPV.
- Statistical comparison of parameters between the isolated CAE group and the control group.
Main Results:
- No significant differences were observed in age, gender, BMI, blood pressure, heart rate, or routine blood parameters between groups.
- Patients with isolated CAE exhibited significantly higher MPV values compared to controls (P < 0.0001).
- C-reactive protein (CRP) levels were also significantly elevated in patients with isolated CAE (P < 0.002).
Conclusions:
- Elevated MPV in isolated CAE suggests increased platelet reactivity and aggregation.
- These findings indicate a potential association between altered platelet function and ischemic events in CAE.
- MPV may serve as a valuable biomarker for assessing cardiovascular risk in patients with isolated CAE.
Abstract:
Coronary artery ectasia (CAE) is frequently considered to be an incidental angiographic finding; however, several reports have shown an association with myocardial ischemia and infarction. In this study, we aimed to evaluate the mean platelet volume (MPV), which is a marker of platelet reactivity, in patients with isolated CAE. In this study we investigated the platelet functions by MPV measurement in patients with isolated CAE. The study population consisted of 23 patients (17 males, 6 females) with isolated CAE (Group-I). Sex-age matched 30 patients (22 males, 8 females) with angiographically proven normal coronary arteries served as the control group (Group-II). Serum total cholesterol, HDL-C, LDL-C, triglyceride level, hemoglobin, white blood cell count, CRP, platelet count and MPV were compared in both groups. There was no significant difference between two groups in terms of age, gender, body mass index, blood pressure and heart rate. Serum total cholesterol, HDL-C, LDL-C, triglyceride level, hemoglobin, white blood cell count, platelet count were also similar in both groups. However, the MPV values of patients with isolated CAE were significantly higher than those of controls (P < 0.0001). In addition to that, CRP levels were found to be significantly higher in patients with isolated CAE (P < 0.002). Increased MPV may indicate the altered platelet reactivity and aggregation and thereby may be associated with ischemic events, observed in patients with isolated CAE.
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