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EBV+ lymphoproliferative disease following prolonged chemotherapy for refractory LCH
Dean A Lee1, Nina Tatevian, Ruth A Herring
1Department of Pediatrics, Hematology/Oncology Section, Baylor College of Medicine, Texas Children's Cancer Center and Hematology Service, Houston, Texas, USA. dalee@mdanderson.org
Abstract:
Epstein-Barr virus (EBV) is a herpesvirus for which latent infection in B lymphocytes occurs in most individuals by middle childhood. Clinically significant reactivation of this virus occurs in the context of suppressed cell-mediated immunity, occasionally developing into lymphoproliferative disease (EBV-LPD). EBV reactivation is rarely associated with intensive chemotherapy alone. Here we present the case of a 4-year-old female who developed EBV-LPD as a complication of prolonged immunosuppressive chemotherapy for her multiply-recurrent Langerhans cell histiocytosis (LCH).