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Practical considerations in development of solid dosage forms that contain cyclodextrin.

Lee A Miller1, Rebecca L Carrier, Imran Ahmed

  • 1Pfizer, Inc., Ann Arbor, Michigan 48105, USA. lee.a.miller@pfizer.com

Journal of Pharmaceutical Sciences
|January 24, 2007
PubMed
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This review explores cyclodextrin use in solid dosage forms, focusing on preparation methods and analytical techniques. It covers physical mixtures, inclusion complexes, and formulation considerations for effective drug delivery.

Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Materials Science

Background:

  • Cyclodextrins are widely used in pharmaceutical formulations to improve drug solubility and stability.
  • Their application in solid dosage forms requires careful consideration of formulation strategies and processing parameters.
  • Existing literature often focuses on cyclodextrin properties, necessitating a review of their practical use in dosage forms.

Purpose of the Study:

  • To review the literature on the application of cyclodextrins in solid dosage forms.
  • To outline the decision-making process for developing cyclodextrin-based solid dosage forms.
  • To discuss key factors influencing the preparation and performance of these formulations.

Main Methods:

  • Literature review focusing on cyclodextrin utilization in solid dosage forms.

Related Experiment Videos

  • Consideration of physical mixture preparation and inclusion complex formation.
  • Analysis of analytical techniques, excipient effects, size limitations, powder processing, and storage.

    • Main Results:

    • A flow diagram is presented to guide the development process of cyclodextrin solid dosage forms.
    • The review details methods for preparing physical mixtures and inclusion complexes.
    • Key factors such as analytical validation, excipient compatibility, and formulation stability are discussed.

    Conclusions:

    • Cyclodextrins offer versatile solutions for enhancing solid dosage form performance.
    • Understanding complexation, processing, and storage is crucial for successful formulation development.
    • This review provides a comprehensive guide for researchers and formulators working with cyclodextrin-based solid dosage forms.