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Updated: Jun 21, 2026
09:38
A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
Published on: February 14, 2017
[Assessment of platelet function in man].
1Inserm U 765, Faculté de Pharmacie, Université Paris 5 et AP-HP, Service d'Hématologie Biologique, Hôpital Européen Georges Pompidou, Paris, France. pascale.gaussem@egp.aphp.fr
Therapie
|January 25, 2007
Summary
Platelet function tests are crucial for diagnosing bleeding disorders and monitoring antiplatelet drugs like aspirin and clopidogrel. Advanced flow cytometry offers comprehensive platelet analysis, including P2Y12 receptor function.
Area of Science:
- Hematology
- Clinical Pathology
- Pharmacology
Context:
- Platelet function assessment is vital for hemostatic disorders.
- It is increasingly used to monitor antiplatelet therapies (aspirin, clopidogrel).
- Traditional methods include platelet counting, morphological analysis, bleeding time, and aggregometry.
Purpose:
- To review current and emerging methods for assessing platelet function.
- To highlight the role of platelet function tests in clinical practice.
- To discuss the utility of flow cytometry in platelet analysis.
Summary:
- While aggregometry is the gold standard, whole blood platelet function analyzers provide rapid assessments.
- Flow cytometry offers a broad spectrum of tests, including receptor analysis, secretion, aggregation, and microparticle quantification.
- A novel flow cytometry method measures VASP protein phosphorylation to assess P2Y12 receptor function, aiding clopidogrel monitoring.
Impact:
- Improved monitoring of antiplatelet therapy efficacy and safety.
- Enhanced diagnosis and management of hemostatic disorders.
- Advancement of personalized medicine through tailored antiplatelet treatment strategies.
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