Related Experiment Video
Updated: Jul 17, 2026

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model
Published on: June 18, 2021
[Subarachnoid hemorrhage as a complication of Le Fort I osteotomy]
Ai Sano1, Satoshi Taie, Ikuo Uekita
1Department of Anesthesiology & Emergency Medicine, Faculty of Medicine, Kagawa University, Kagawa 761-0793.
Insights
Le Fort I osteotomy can cause serious intracranial vascular injuries like subarachnoid hemorrhage (SAH) and carotid cavernous fistula (CCF). Prompt treatment with coil embolization and hypothermia led to a good recovery, highlighting the need to monitor for bleeding during surgery.
Area of Science:
- Neurosurgery
- Oral and Maxillofacial Surgery
- Vascular Surgery
Background:
- Le Fort I osteotomy is a surgical procedure used to correct midface hypoplasia, often associated with cleft lip and palate repair.
- Intracranial vascular complications are rare but serious risks associated with craniofacial surgeries.
Observation:
- A 16-year-old male undergoing Le Fort I osteotomy for cleft lip and palate experienced massive bleeding (>1000 ml) post-fracture.
- Postoperatively, the patient presented with anisocoria and left-sided hemiparesis, indicating potential neurological compromise.
Findings:
- Computed tomography (CT) and angiography confirmed the presence of carotid cavernous fistula (CCF) and subarachnoid hemorrhage (SAH).
- The patient underwent successful coil embolization for the CCF and therapeutic hypothermia for the SAH.
Implications:
- Unexpected intraoperative hemorrhage during Le Fort I osteotomy should raise suspicion for intracranial vascular injury.
- Early diagnosis and intervention, including endovascular techniques and neuroprotective measures, are crucial for favorable outcomes in such cases.
Abstract:
We report a case of subarachnoid hemorrhage (SAH) and carotid cavernous fistula (CCF) caused by Le Fort I osteotomy. A 16-year-old boy was scheduled to undergo Le Fort I osteotomy for a cleft lip and palate. After down fracture was completed, more than 1000 ml of bleeding was observed. When he became concious, we found anisocoria and imcomplete paralysis in the left side of his body. CT and angiography showed CCF and SAH to be present. After coil embolisation for CCF and therapeutic hypothermia had been performed, he recovered without severe neurological deficits. We should remember that unexpected mass bleeding in this surgery would suggest the incidence of intracranial vascular injuries.
Related Concept Videos
Hemorrhagic Stroke ll: Pathophysiology
Hemorrhagic Stroke l: Introduction
Aneurysm III: Interprofessional Care

