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Updated: Jul 17, 2026
Microsatellite DNA Genotyping and Flow Cytometry Ploidy Analyses of Formalin-fixed Paraffin-embedded Hydatidiform Molar Tissues
Published on: October 20, 2019
Increased adenosine deaminase in hydatidiform mole
Yaprak Engin-Ustün1, Yusuf Ustün, Aysun Bay Karabulut
1Department of Obstetrics and Gynecology, School of Medicine, Inonu University, Malatya, Turkey. ustunyaprak@yahoo.com
Background:
The aim of the current study was to investigate levels of adenosine deaminase in plasma of patients with hydatidiform mole.
Methods:
Plasma adenosine deaminase levels were determined in 17 women with normal pregnant course, in 17 women with hydatidiform mole, and in 17 non-pregnant healthy volunteers.
Results:
Mean adenosine deaminase activity in the hydatidiform mole group was 121.5+/-24.8 U/L, significantly higher than in the pregnant control (7.8+/-6.5 U/L; p<0.0001) and non-pregnant control groups (6.4+/-7.4 U/L; p<0.0001). A cutoff level of 40.5 U/L was found, with both sensitivity and specificity of 100%.
Conclusions:
Adenosine deaminase may play a role in the development of hydatidiform mole.
