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Updated: Jul 17, 2026

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

Published on: April 26, 2012

Nail changes associated with chemotherapy in children.

W Chen¹, Y-S Yu, Y-H Liu

¹Department of Dermatology, Chang Gung Memorial Hospital, Kaohsiung Medical Centre, Chang Gung University, College of Medicine, Kaohsiung, Taiwan. wchen@cgmh.org.tw

Journal of the European Academy of Dermatology and Venereology : JEADV

|January 25, 2007

Summary

Chemotherapy can cause nail changes in children with cancer, with Muehrcke

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Last Updated: Jul 17, 2026

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

Published on: April 26, 2012

Area of Science:

Pediatric Oncology
Dermatology
Clinical Pharmacology

Background:

Chemotherapy-induced nail changes in pediatric patients are infrequently documented.
Understanding these side effects is crucial for supportive care in pediatric oncology.

Purpose of the Study:

To investigate the occurrence and characteristics of nail abnormalities in children undergoing chemotherapy.
To identify patterns and onset of nail changes in relation to cancer type and treatment.

Main Methods:

A cross-sectional study involving 30 pediatric patients (ages 1-17) with various cancers.
Patients received diverse chemotherapy regimens, and nail changes were systematically observed.

Main Results:

Nail changes were observed in 10 children (33.3%) during chemotherapy.
Muehrcke's lines were the most frequent finding (5 cases), followed by Beau's lines (3 cases).
No clear correlation was found between nail alterations and cancer type, stage, or chemotherapy regimen.

Conclusions:

Approximately one-third of pediatric cancer patients experienced chemotherapy-related nail changes.
Muehrcke's lines were the predominant manifestation and were not associated with hypoalbuminemia in this cohort.
Nail changes represent a notable side effect requiring clinical attention in pediatric cancer care.