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Sequence of the rabbit neurofilament protein L
D R Soppet1, L L Beasley, M B Willard
1Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri 63110.
Journal of Neuroscience Research
|September 1, 1991
Abstract:
In the course of screening a rabbit brain cDNA library with a probe for the H neurofilament protein, we identified a neurofilament L-cDNA. Its nucleotide sequence is 88% identical to that of human, indicating that L is highly conserved among species. The similarities between the sequences of L from rabbit and mouse suggest that the species-specific accumulation of neurofilaments that occurs in rabbit during aluminum intoxication is not a consequence of the primary structure of L.