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Published on: September 16, 2011
Functional eicosanoid test and typing (FET) in acetylsalicylic acid intolerant patients with urticaria
F W Velten1, C Bayerl, H W Baenkler
1Department of Dermatology and Allergology, University Medical Center Mannheim, Ruprecht-Karls-University of Heidelberg, Mannheim, Germany. florian.velten@haut.ma.uni-heidelberg.de
Abstract:
One of the common side effects of acetylsalicylic acid (ASA) is the induction of pseudoallergic reactions that range from urticarial wheals to anaphylactic shock. At present there is no reliable detection method available for the diagnosis of ASA-hypersensitivity and its relation to clinical symptoms. The purpose of the present study was to evaluate the functional eicosanoid typing (FET) score taking into account several parameters of the equilibrium between prostaglandins (PG) and peptido-leukotriens (pLT). A total eicosanoid pattern score (TEP) ranging from 0.0 to 3.0, was defined that exhibited significant differences (p
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