Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chronic enteropathy: molecular basis.

Frank M Ruemmele1

  • 1Pediatric Gastroenterology, Hepatology and Nutrition, INSERM U793, Hôpital Necker-Enfants Malades, 149 Rue de Sèvres, FR-75743 Paris Cedex 15, France. frank.ruemmele@nck.ap-hop-paris.fr

Nestle Nutrition Workshop Series. Paediatric Programme
|January 25, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cyclic exclusive enteral nutrition in paediatric Crohn's disease - Authors' reply.

The lancet. Gastroenterology & hepatology·2026
Same author

Cyclic exclusive enteral nutrition versus partial enteral nutrition to maintain long-term drug-free remission in paediatric Crohn's disease (CD-HOPE): an open-label, endpoint-blinded, randomised controlled trial.

The lancet. Gastroenterology & hepatology·2026
Same author

Long-Term Outcome of Paediatric Crohn's Disease Patients With Deep Ulcerations at Diagnosis.

Acta paediatrica (Oslo, Norway : 1992)·2025
Same author

Altered chaperone-nonmuscle myosin II interactions drive pathogenicity of the UNC45A c.710T>C variant in osteo-oto-hepato-enteric syndrome.

JCI insight·2025
Same author

Gut-homing and intestinal TIGIT<sup>neg</sup>CD38<sup>+</sup> memory T cells acquire an IL-12-induced, ex-Th17 pathogenic phenotype in a subgroup of Crohn's disease patients with a severe disease course.

Mucosal immunology·2024
Same author

Combined plasma protein and memory T cell profiling discern IBD-patient-immunotypes related to intestinal disease and treatment outcomes.

Mucosal immunology·2024
Same journal

Early nutrition: impact on short- and long-term health. Concluding remarks.

Nestle Nutrition workshop series. Paediatric programme·2011
Same journal

Igf-I signaling and effects on longevity.

Nestle Nutrition workshop series. Paediatric programme·2011
Same journal

Early life nutrition and bone development in children.

Nestle Nutrition workshop series. Paediatric programme·2011
Same journal

Infant feeding practices and subsequent development of adipose tissue.

Nestle Nutrition workshop series. Paediatric programme·2011
Same journal

Early feeding practices and their impact on development of celiac disease.

Nestle Nutrition workshop series. Paediatric programme·2011
Same journal

Learning to prefer the familiar in obesogenic environments.

Nestle Nutrition workshop series. Paediatric programme·2011
See all related articles

Chronic intractable diarrhea in infants involves two main types: congenital enteropathies with intrinsic defects and immunoinflammatory enteropathies. Understanding their molecular basis offers hope for new treatments for affected children.

Area of Science:

  • Pediatric Gastroenterology
  • Immunology
  • Genetics

Background:

  • Chronic intractable diarrhea in infancy is a heterogeneous group of disorders.
  • Advances in understanding pathophysiology allow for a new conceptual view.
  • Two major types of chronic enteropathies can be distinguished.

Purpose of the Study:

  • To differentiate between congenital-constitutive and immunoinflammatory enteropathies.
  • To highlight the genetic basis of certain infantile diarrheal disorders.
  • To discuss the implications for future treatment strategies.

Main Methods:

  • Morphological-histological classification of congenital enteropathies.
  • Identification of genetic mutations, such as in the FOXP3 gene.

Related Experiment Videos

  • Investigation of regulatory T cell defects in autoimmune enteropathies.

    • Main Results:

    • Congenital-constitutive enteropathies show intrinsic enterocyte defects (e.g., microvillous inclusion disease, intestinal epithelial dysplasia).
    • Immunoinflammatory enteropathies may present with extraintestinal symptoms and include X-linked autoimmune enteropathy due to FOXP3 mutations.
    • FOXP3 mutations indicate a defect in regulatory T cells.

    Conclusions:

    • Understanding the molecular basis of these diarrheal disorders is crucial.
    • New treatment strategies are expected to emerge, offering hope for critically ill infants.
    • Further research into FOXP3 mutations and regulatory T cell function is warranted.