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Hyperthermic intraperitoneal chemoperfusion (HIPEC) decrease wound strength of colonic anastomosis in a rat model
J O W Pelz1, J Doerfer, M Decker
1Department of Surgery, University of Erlangen-Nuremberg, Krankenhausstrasse 12, 91054, Erlangen, Germany.. joerg.pelz@chir.imed.uni-erlangen.de
International Journal of Colorectal Disease
|January 25, 2007
Summary
Hyperthermic intraperitoneal chemoperfusion (HIPEC) negatively impacts colonic anastomosis healing in rats. Both pre- and post-anastomosis HIPEC reduced bursting pressure and collagen, indicating impaired wound healing.
Area of Science:
- Surgical oncology
- Gastrointestinal surgery
- Wound healing research
Background:
- Controversy exists regarding hyperthermia and chemotherapy's effects on intestinal anastomosis healing.
- Hyperthermic intraperitoneal chemoperfusion (HIPEC) is a treatment modality with potential impacts on surgical sites.
Purpose of the Study:
- To investigate the effects of HIPEC on colonic anastomosis wound healing in a rat model.
- To evaluate the influence of HIPEC timing (pre- vs. post-anastomosis) on healing outcomes.
Main Methods:
- Thirty-six rats underwent colonic anastomosis and were randomized into control, pre-HIPEC, and post-HIPEC groups.
- Hyperthermic intraperitoneal chemoperfusion utilized mitomycin C (20 mg/m²).
- Outcomes assessed included bursting pressure, collagen deposits, inflammation, and foreign body reactions at 4 and 10 days.
Main Results:
- Both HIPEC groups exhibited significantly lower bursting pressure compared to the control group.
- Reduced collagen deposition was observed in HIPEC groups, correlating with lower bursting pressure.
- No significant difference in healing impairment was noted between pre- and post-anastomosis HIPEC.
Conclusions:
- HIPEC significantly impairs wound healing in colonic anastomosis in a rat model.
- The timing of HIPEC relative to anastomosis does not alter the negative impact on healing.
- Findings suggest careful consideration of HIPEC in patients with colonic anastomosis.
