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Related Experiment Videos

Septamycin, a polyether antibiotic. Taxonomy, fermentation, isolation and characterization.

C Keller-Juslén, H D King, Z L Kis

    The Journal of Antibiotics
    |November 1, 1975
    PubMed
    Summary

    Septamycin, a polyether antibiotic from Streptomyces hygroscopicus, is identical to antibiotic A28695 A. This metabolite shows activity against gram-positive bacteria and Eimeria tenella.

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    Area of Science:

    • Microbiology
    • Natural Product Chemistry
    • Structural Biology

    Background:

    • Septamycin is a metal-complexing polyether antibiotic.
    • It is produced by Streptomyces hygroscopicus NRRL 5678.
    • The antibiotic has a complex structure with a thirty-carbon backbone and seven heterocyclic rings.

    Purpose of the Study:

    • To characterize septamycin, a novel antibiotic.
    • To determine the crystal structure and absolute configuration of septamycin.
    • To compare septamycin with other known antibiotics.

    Main Methods:

    • Isolation and purification of septamycin as its sodium salt (C48H81NaO16).
    • X-ray crystallographic analysis of the p-bromophenacyl derivative for structural determination.
    • Direct comparison with antibiotic A28695 A for identity confirmation.

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    Main Results:

    • The chemical structure and absolute configuration of septamycin were established.
    • Septamycin was confirmed to be identical to antibiotic A28695 A.
    • The metabolite demonstrated antimicrobial activity against gram-positive bacteria.

    Conclusions:

    • Septamycin is a structurally defined polyether antibiotic.
    • It possesses biological activity relevant to infectious diseases.
    • The identity with A28695 A suggests a common origin or biosynthetic pathway.