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Related Experiment Videos

[Large cell anaplastic lymphomas in the immunocompromised host].

B Borisch1, M F Fey, A Tobler

  • 1Pathologisches Institut, Universität Bern.

Verhandlungen Der Deutschen Gesellschaft Fur Pathologie
|January 1, 1991
PubMed
Summary

Large cell anaplastic (LCA) lymphoma, a new tumor entity, was studied in renal transplant patients. Epstein-Barr Virus (EBV) infection may precede clonal evolution in B-cell lymphomagenesis.

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Area of Science:

  • Oncology
  • Immunology
  • Transplantation

Background:

  • Large cell anaplastic (LCA) lymphoma is a recently defined tumor entity.
  • CD30+ LCA lymphoma in renal transplant recipients is rare, with only one prior report.
  • This study investigates two cases of LCA lymphoma in renal transplant patients.

Purpose of the Study:

  • To describe two cases of B-cell phenotype LCA lymphoma in renal transplant patients.
  • To analyze the clonal evolution of these lymphomas.
  • To investigate the potential etiologic role of Epstein-Barr Virus (EBV) in LCA lymphoma development.

Main Methods:

  • Case study of two renal transplant patients with LCA lymphoma.
  • Analysis of B-cell phenotype.
  • Investigation of clonal evolution using molecular techniques.

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  • Assessment of Epstein-Barr Virus (EBV) infection status and proliferation.

    • Main Results:

    • Both lymphomas were of B-cell phenotype.
    • Clonal evolution was observed in the B-cell populations.
    • Evidence suggests EBV infection, either primary or reactivated latent, preceded clonal EBV proliferation and lymphomagenesis.

    Conclusions:

    • Clonal evolution of B-cell populations appears to be a secondary event in lymphomagenesis.
    • EBV infection, particularly clonal EBV proliferation, may play a significant role in the development of LCA lymphoma in renal transplant patients.