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Related Experiment Videos

Mutable R-navajo alleles of cyclic origin in maize.

R A Brink1, E Williams

  • 1Laboratory of Genetics, University of Wisconsin, Madison, Wisconsin 53706.

Genetics
|February 1, 1973
PubMed
Summary
This summary is machine-generated.

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Researchers generated 26 mutable R-Navajo (mR(nj)) alleles in maize by cyclically transposing Modulator (Mp) near the R locus. These alleles showed varied mutability but consistent effects on chromosome breakage and pericarp stability.

Area of Science:

  • Genetics and Molecular Biology
  • Plant Genetics
  • Maize Genetics

Background:

  • The R-Navajo (R(nj)) allele in maize is subject to regulation by the Modulator (Mp) element.
  • Transposition of Mp influences gene expression and chromosomal stability.
  • Understanding these dynamic genetic elements is crucial for maize breeding and genetic studies.

Purpose of the Study:

  • To investigate the generation and characteristics of mutable R-Navajo (mR(nj)) alleles in maize.
  • To analyze the relationship between Mp transposition and gene derepression at the R locus.
  • To examine the effects of reconstituted mR(nj) alleles on other genetic phenomena like Ds chromosome breakage and variegated pericarp stability.

Main Methods:

  • Cyclic transposition of the Modulator (Mp) element to and from the R-Navajo (R(nj)) locus in maize.

Related Experiment Videos

  • Generation and characterization of 26 distinct mutable R-Navajo (mR(nj)) alleles.
  • Assessment of allele mutability, Mp transposition frequency, Ds chromosome breakage activation, and variegated pericarp stability.

    • Main Results:

    • Successfully generated 26 mR(nj) alleles with continuous variation in mutability.
    • Observed consistent activation of Ds chromosome breakage and increased stability of variegated pericarp across the reconstituted alleles.
    • Postulated that Mp is intercalated at different sites within each mR(nj) allele, influencing transposition frequency.

    Conclusions:

    • The study elucidates a mechanism for generating diverse mutable alleles in maize through Mp transposition.
    • The findings suggest that nucleotide sequences flanking Mp influence its release and transposition frequency.
    • A chromosome model involving DNA nicking and replication is proposed to explain Mp transposition dynamics.