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Related Concept Videos

Conservative Site-specific Recombination and Phase Variation02:53

Conservative Site-specific Recombination and Phase Variation

Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...
Gene Conversion02:08

Gene Conversion

Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
Gene Conversion02:08

Gene Conversion

Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
Crossing Over01:30

Crossing Over

Crossing over is the exchange of genetic information between homologous chromosomes during prophase I of meiosis I. Genetic recombination gives rise to allelic diversity in the newly formed daughter cells. In humans, crossing over produces genetically distinct haploid egg and sperm cells that undergo fertilization to produce unique offspring. Before cell division starts, the germ cell’s chromosome(s) undergo duplication in the S phase of the cell cycle. As the cells enter prophase I, duplicated...
Dihybrid Crosses01:18

Dihybrid Crosses

Overview
Mismatch Repair01:20

Mismatch Repair

Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...

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Related Experiment Video

Updated: Jul 17, 2026

Recombineering Homologous Recombination Constructs in Drosophila
14:23

Recombineering Homologous Recombination Constructs in Drosophila

Published on: July 13, 2013

Selection for Linkage Modification II. a Recombination Balance for Neutral Modifiers.

M W Feldman1, B Balkau

  • 1Department of Biological Sciences, Stanford University, Stanford, California 94305.

Genetics
|August 1, 1973
PubMed
Summary

A gene controlling recombination can create stable genetic diversity. This occurs when heterozygotes maximize linkage disequilibrium, analogous to heterozygous advantage, promoting higher population fitness.

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Subcloning Plus Insertion (SPI) - A Novel Recombineering Method for the Rapid Construction of Gene Targeting Vectors
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Subcloning Plus Insertion (SPI) - A Novel Recombineering Method for the Rapid Construction of Gene Targeting Vectors

Published on: January 8, 2015

Related Experiment Videos

Last Updated: Jul 17, 2026

Recombineering Homologous Recombination Constructs in Drosophila
14:23

Recombineering Homologous Recombination Constructs in Drosophila

Published on: July 13, 2013

Subcloning Plus Insertion (SPI) - A Novel Recombineering Method for the Rapid Construction of Gene Targeting Vectors
09:02

Subcloning Plus Insertion (SPI) - A Novel Recombineering Method for the Rapid Construction of Gene Targeting Vectors

Published on: January 8, 2015

Area of Science:

  • Population genetics
  • Evolutionary biology
  • Quantitative genetics

Background:

  • Gene regulation and its impact on genetic diversity are crucial in evolutionary processes.
  • Understanding the mechanisms maintaining polymorphism is a key challenge in population genetics.

Purpose of the Study:

  • To investigate the conditions under which a selectively-neutral gene locus can maintain stable polymorphism.
  • To explore the role of recombination modulation in establishing genetic diversity.

Main Methods:

  • Theoretical modeling of gene interactions.
  • Analysis of linkage disequilibrium dynamics.
  • Simulation of population genetic models.

Main Results:

  • A stable polymorphic equilibrium can be established at a neutral locus controlling recombination.
  • The condition for stable polymorphism is analogous to heterozygous advantage.
  • Heterozygotes at the modifier locus should yield a recombination fraction maximizing linkage disequilibrium and mean fitness.

Conclusions:

  • Recombination rate modification by a neutral locus can be a powerful mechanism for maintaining genetic polymorphism.
  • These findings offer insights into the evolution of coadaptation and complex genetic architectures.
  • The study highlights the interplay between selection, recombination, and genetic diversity.