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Related Concept Videos

Multiple Allele Traits01:49

Multiple Allele Traits

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Epistasis Analysis

Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of phenotypes. When the interaction of various genes or alleles at different locations influences a phenotype, this is called epistasis. Epistasis often involves one gene masking or interfering with the expression of another (antagonistic epistasis). Epistasis often occurs when different genes are part of the same biochemical pathway. The...
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
Hardy-Weinberg Principle01:49

Hardy-Weinberg Principle

Diploid organisms have two alleles of each gene, one from each parent, in their somatic cells. Therefore, each individual contributes two alleles to the gene pool of the population. The gene pool of a population is the sum of every allele of all genes within that population and has some degree of variation. Genetic variation is typically expressed as a relative frequency, which is the percentage of the total population that has a given allele, genotype or phenotype.In the early 20th century,...
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Modern Molecular Taxonomy

Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...

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Related Experiment Video

Updated: Jul 17, 2026

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
10:17

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

An analysis of multi-allelic data.

G A Watterson1

  • 1Mathematics Department, Monash University, Clayton, Victoria, Australia 3168.

Genetics
|January 1, 1978
PubMed
Summary

Analysis of multi-allelic data suggests strict neutrality is unlikely. However, distinguishing further alleles could support the neutral theory of molecular evolution as a possible explanation.

Area of Science:

  • Evolutionary biology
  • Population genetics

Background:

  • The neutral theory of molecular evolution proposes that most genetic variation is due to neutral mutations.
  • Empirical data is crucial for testing the validity of the neutral theory.

Purpose of the Study:

  • To assess the compatibility of existing multi-allelic data with the neutral alleles theory.
  • To investigate factors influencing the interpretation of genetic variation under neutrality.

Main Methods:

  • Analysis of multi-allelic genetic data from Coyne (1976) and Singh, Lewontin, and Felton (1976).
  • Statistical evaluation of observed genetic variation against predictions of the neutral theory.

Main Results:

  • The analyzed data, as is, does not strictly support the neutral alleles theory.

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Last Updated: Jul 17, 2026

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
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  • A potential explanation for neutrality emerges if finer distinctions among alleles are considered.

    • Conclusions:

    • Strict neutrality may not fully explain the observed genetic variation in the studied samples.
    • Further resolution of allelic distinctions could reconcile the data with neutral evolution models.