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Human chronic fascioliasis: hepatitis B and C among infected cases

A G Farghaly1, H N el-Morshedy, S A Sharaf

  • 1Tropical Health Department, High Institute of Public Health.

The Journal of the Egyptian Public Health Association
|January 26, 2007
PubMed

Insights

This study found no significant liver enzyme changes in chronic Fasciola infections. However, hepatitis B virus (HBV) and hepatitis C virus (HCV) markers were more prevalent in older individuals.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Parasitology

Background:

  • Chronic Fasciola infection can affect liver health.
  • Hepatitis B virus (HBV) and hepatitis C virus (HCV) are significant public health concerns.
  • Co-infections or concurrent conditions require investigation.

Purpose of the Study:

  • To investigate the prevalence of hepatitis B and C markers in chronic Fasciola cases.
  • To assess the impact of these viral markers on liver function tests in the study population.
  • To explore familial aggregation of hepatitis markers.

Main Methods:

  • Screening of sera from 153 chronic Fasciola cases for hepatitis B surface antigen (HBsAg), anti-hepatitis B core (anti-HBc), anti-hepatitis B surface (anti-HBs), and anti-hepatitis C virus (anti-HCV) using ELISA.
  • Quantitative stool examination.
  • Estimation of liver enzymes (AST, ALT, bilirubin).

Main Results:

  • Prevalence rates: HBsAg (3.3%), anti-HBs (8.5%), hepatitis B exposed (HBex) (28.8%), and anti-HCV (8.5%).
  • HBV and HCV markers were significantly higher in older age groups.
  • No significant changes were observed in Fasciola egg counts or liver function tests.

Conclusions:

  • Chronic Fasciola infection did not significantly alter liver function tests or Fasciola egg counts.
  • A notable prevalence of HBV and HCV markers exists within the chronic Fasciola patient group, particularly in older individuals.
  • Familial aggregation of HBV exposure was observed in a subset of HBex cases.

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