Rare presentation of leucocytosis

Area of Science:

• Hematology
• Oncology

Background:

• Chronic Neutrophilic Leukaemia (CNL) is a rare myeloproliferative neoplasm characterized by sustained high neutrophil counts.
• Accurate diagnosis and effective treatment strategies for CNL remain challenging due to its rarity.

Observation:

• A 44-year-old male patient presented with persistent leucocytosis.
• Diagnostic workup confirmed the diagnosis of Chronic Neutrophilic Leukaemia.

Findings:

• The patient exhibited resistance to standard therapeutic interventions for CNL.
• Ten months post-diagnosis, the condition remained refractory to treatment.

Implications:

• This case highlights the challenges in managing treatment-refractory Chronic Neutrophilic Leukaemia.
• Further research into novel therapeutic targets and treatment protocols for CNL is warranted.