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Updated: Jul 17, 2026

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
07:54

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Published on: December 21, 2019

[Malignant pleural mesothelioma]

O Kawamata1, Y Kondu, T Murata

  • 1Department of Surgery, Onomichi Municipal Hospital, Onomichi, Japan.

Kyobu Geka. the Japanese Journal of Thoracic Surgery
|January 26, 2007
PubMed

Insights

This study reviewed 15 malignant pleural mesothelioma cases, noting varied histology and treatments. Survival outcomes highlight the need for improved therapeutic strategies for this poor-prognosis cancer.

Area of Science:

  • Oncology
  • Thoracic Surgery
  • Pathology

Context:

  • Malignant pleural mesothelioma (MPM) is an aggressive cancer with limited treatment options.
  • No established standard therapy exists for MPM, contributing to its poor prognosis.

Purpose:

  • To analyze clinical features and outcomes of 15 patients with malignant pleural mesothelioma.
  • To evaluate the impact of chemotherapy and extrapleural pneumonectomy (EPP) on survival in MPM patients.

Summary:

  • Fifteen MPM cases (14 male, 1 female; age 38-81) were diagnosed via thoracoscopic pleural biopsy.
  • Histological subtypes included epithelial (8), biphasic (3), sarcomatous (2), and desmoplastic malignant mesothelioma (DMM) (2).
  • Twelve patients received chemotherapy, with 3 undergoing subsequent surgery; 4 had extrapleural pneumonectomy (EPP).

Impact:

  • Six patients survived, with the longest survival being 41 months with chemotherapy and 25 months with EPP.
  • The 2-year survival rate was 44.4%, and median survival for epithelial mesothelioma was 30.6 months.
  • Findings underscore the challenges in MPM treatment and the need for novel therapeutic approaches.

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