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Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
Published on: December 21, 2019
[Extrapleural pneumonectomy for malignant pleural mesothelioma]
T Morohoshi1, T Yamamoto, T Nagashima
1Department of Thoracic Surgery, Yokosuka Kyosai Hospital, Yokosuka, Japan.
Kyobu Geka. the Japanese Journal of Thoracic Surgery
|January 26, 2007
Summary
Extrapleural pneumonectomy (EPP) can improve survival for select malignant pleural mesothelioma (MPM) patients. Success is linked to epithelial type, negative nodes, and no residual tumors post-surgery.
Area of Science:
- Oncology
- Thoracic Surgery
- Pulmonary Medicine
Context:
- Malignant pleural mesothelioma (MPM) is an aggressive cancer.
- Extrapleural pneumonectomy (EPP) is a radical surgical option for MPM.
- Patient selection is critical for surgical outcomes.
Purpose:
- To evaluate the outcomes of extrapleural pneumonectomy (EPP) in a cohort of malignant pleural mesothelioma (MPM) patients.
- To identify factors associated with improved survival after EPP for MPM.
Summary:
- This study analyzed 14 male patients (mean age 58.5 years) with malignant pleural mesothelioma (MPM) who underwent extrapleural pneumonectomy (EPP).
- Preoperative diagnoses included 12 epithelial, 1 biphasic, and 1 sarcomatous type. Postoperative staging revealed 3 Stage II, 8 Stage III, and 3 Stage IV cases.
- The operative mortality rate was 7% (1 death), with a 50% morbidity rate. Median survival was 20.2 months, with 2-year and 5-year survival rates of 33% and 8.3%, respectively.
Impact:
- Extrapleural pneumonectomy (EPP) demonstrates potential for improving survival in carefully selected malignant pleural mesothelioma (MPM) patients.
- Positive outcomes are associated with epithelial histology, negative lymph node status, and complete resection (no residual tumor).
- These findings support refined patient selection criteria for EPP in MPM management.
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