Fibre divergence in the distal optic radiation: possible basis of functional plasticity in adult primate visual...

The precision of retinotopy in primate visual cortex is commonly thought to result from highly ordered arrangement of fibres in the visual pathways. However, rigid point-to-point representation is hardly compatible with findings of a substantial reorganization of visual cortical maps after peripheral and central lesions. Such observations could be accounted for by divergence in the optic radiation. To explore the hypothesis of fibre divergence, we made small knife cuts in the distal optic radiation of macaca fascicularis. After subsequent axonal tracing by injecting WGA-HRP into lateral geniculate nucleus, we studied the course of distal fibres in white matter. The amount of divergence was assessed by measuring, relative to the prevailing fibre course, length and orientation of labelled fibres between lesion and entry into cortex. Lesion sizes between 1 mm to 3 mm did not result in any detectable diminution of terminal labelling in layer IVC of striate cortex. Individual labelled fibres were found to diverge symmetrically from both sides into the gap distal to the lesion. Divergence starts at a distance of about 3 mm before cortex. At the white matter boundary, less than 10% of all fibres still retain the original direction, with the remaining fibres taking any other orientation without preference. We estimate that this corresponds to a divergence of visual afferents encompassing about 6-10 mm of cortical distance, if intracortical arborization of terminal fibres is taken into account. Possible consequences for functional plasticity in the adult primate visual cortex are discussed.