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Mapping of linear B-cell epitopes of hepatitis B surface antigen
P Coursaget1, G Lesage, P Le Cann
1Institut de Virologie de Tours and Laboratoire de Microbiologie-Immunologie, Faculté de Pharmacie, France.
Research in Virology
|November 1, 1991
Abstract:
Eight monoclonal antibodies directed against the surface protein of hepatitis B virus (HBV) were tested using an epitope-mapping system (Pepscan) for characterizing antigenic domains. Four different amino acid sequences corresponding to linear epitopes were identified: one in pre-S1 corresponding to the sequence 29-36, two in pre-S2 corresponding to overlapping sequences 134-141 and 137-144, and one in the S region of the protein corresponding to the amino acid sequence 117-126.